A randomized, double-blind, placebo-controlled trial
Authors: Walker AF, Marakis G, Simpson E, et al.
Journal: Journal of Cardiovascular Pharmacology. 2002; 40(5): 796-804.
Summary:
This study investigated the effects of a standardized extract of hawthorn berry on cardiovascular disease risk factors in 36 patients with mildly elevated cholesterol levels. The patients were randomly assigned to receive either the hawthorn berry extract or a placebo for 10 weeks. Blood pressure, cholesterol levels, and other cardiovascular risk factors were measured at baseline and after 10 weeks of treatment.
Results:
The study found that the hawthorn berry extract significantly reduced diastolic blood pressure compared to placebo. Total cholesterol, LDL cholesterol, and triglyceride levels were also reduced in the hawthorn group, although the differences were not statistically significant. No significant adverse effects were reported.
Conclusion:
The study suggests that a standardized extract of hawthorn berry may have beneficial effects on cardiovascular risk factors, particularly blood pressure. However, larger and longer-term studies are needed to confirm these findings and determine the optimal dose and duration of treatment.